The White Sox have lost 12 games in a row after falling 9-0 against the Orioles Tueday as +274 road underdogs.
Chicago was held scoreless for the 16th time this year.
The White Sox are 11 losses away from tying the 1962 New York Mets for most losses in a season since 1900.
The Orioles have won 3 games in a row after Tuesday’s victory as -310 home favorites.
RF Anthony Santander and LF Colton Cowser each drove in 2 runs while LHP Cade Povich pitched 7 1/3 shutout innings to pick up the win.
Cade Povich struck out 10 while pitching into the eighth inning, and the Baltimore Orioles took a big early lead on their way to a 9-0 victory over the White Sox on Tuesday night, sending Chicago to its 12th consecutive loss.
The White Sox dropped to 31-109 and became the first team since 1900 with at least three losing streaks of 12 games in the same season, according to Sportradar.
The 1889 Louisville Colonels and 1899 Cleveland Spiders also did it.
Chicago was shut out of the 16th time, is 11 defeats shy of tying the 1962 New York Mets for the most losses since 1900 and is on pace to finish 36-126.
Patrick Corbin continued his recent stretch of solid starts with 5 2/3 innings of two-run ball and Joey Gallo hit a three-run homer for the Nationals, who are 8-0 against the Marlins this season after going 6-26 against their NL East opponent the previous two seasons.