The Bees have recorded just one home win in all competitions this season, with the win coming against Burnley in the Premier League last month.
They have a 100% record in Premier League games against the visitors, scoring eight times and conceding just once.
Thomas Frank has a long list of absentees for the match while Rico Henry, Kevin Schade, Joshua Dasilva, Mikkel Damsgaard and Keane Lewis-Potter are confirmed absent with injuries.
Shandon Baptiste has recovered well from his shoulder injury, but the match comes too soon for him.
The Hammers returned to winning ways after three straight defeats in all competitions with a convincing 3-1 victory over Arsenal in the Carabao Cup on Wednesday.
They will look to continue this form in this match.
David Moyes has a medical certificate for the trip to west London but will be without Lucas Paquetá and Edson Álvarez, who are serving a one-match ban after picking up their fifth yellow card of the season last week.
Looking at the hosts’ record against the visitors in the Premier League, they are strong favorites but have a long list of absentees which could impact their performances.
The visitors fielded an almost full squad in their Carabao Cup match against Arsenal on Wednesday.
They will be playing their fourth game in eight days so fatigue will be a factor.
With this in mind, we encourage the two London rivals to play out a low-scoring draw.
Prediction: Brentford 1-1 West Ham United